Chelsea will play Paris Saint-Germain in the Champions League round of 16.
while Manchester City will face Real Madrid in the knockout stages for the fifth consecutive season.
Although six Premier League clubs have qualified for the last 16, there will be no all-English tie, with leaders Arsenal facing Bayer Leverkusen.
Newcastle United will face Barcelona, ​​Liverpool will face Galatasaray; and Tottenham will face Atletico Madrid.
The first legs will be played on March 10 and 11, while the second legs will be played on March 17 and 18.
Newcastle hosts Barca for their first leg, while their Premier League rivals host their second leg and have qualified for the last 16.
Chelsea’s clash with PSG is a rematch of last year’s FIFA Club World Cup final, when the Blues beat PSG 3-0 in New Jersey.
“It will be difficult, but there is no fear for us,” Chelsea’s director of football, David Bernard, said.
Manchester City, Newcastle, and Liverpool all met their opponents during the league stage of this season’s competition.
If Newcastle and Tottenham both advance, they will meet in the quarter-finals, as will Chelsea and Liverpool in the other half of the draw.
The final will be played at the Puskás Arena in Budapest, Hungary, on Saturday, May 30.
